Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

Previous studies have identified the critical role of the left fusiform cortex in visual word form processing, learning, and memory. However, this so-called visual word form area's other functions are not clear. In this study, we used fMRI and the subsequent memory paradigm to examine whether the putative VWFA was involved in the processing and successful memory encoding of faces as well as words. Twenty-two native Chinese speakers were recruited to memorize the visual forms of faces and Chinese words. Episodic (...) memory for the studied material was tested 3. h after the scan with a recognition test. The fusiform face area and the VWFA were functionally defined using separate localizer tasks. We found that, both within and across subjects, stronger activity in the VWFA was associated with better recognition memory of both words and faces. Furthermore, activation in the VWFA did not differ significantly during the encoding of faces and words. Our results revealed the important role of the so-called VWFA in face processing and memory and supported the view that the left mid-fusiform cortex plays a general role in the successful processing and memory of different types of visual objects. © 2010 Elsevier Inc. (shrink)

Learning disabilities are highly prevalent on college campuses, yet students with learning disabilities graduate at lower rates than those without disabilities. Academic and psychosocial supports are essential for overcoming challenges and for improving postsecondary educational opportunities for students with learning disabilities. A holistic, multi-level model of campus-based supports was established to facilitate culture and practice changes at the institutional level, while concurrently bolstering mentors’ abilities to provide learning disability-knowledgeable support, and simultaneously creating opportunities for students’ personal and interpersonal development. Mixed (...) methods were used to investigate implementation of coordinated personal, interpersonal, and institutional level supports for undergraduate science, technology, engineering, and math (STEM) students with learning disabilities. A one-group pre-test post-test strategy was used to examine undergraduate outcomes. Participants included 52 STEM undergraduates with learning disabilities, 57 STEM graduate student mentors, 34 STEM faculty mentors, and 34 university administrators and personnel as members of a university-wide council. Enrolled for two years, undergraduates were engaged in group meetings involving psychoeducation and reflective discussions, development of self-advocacy projects, and individual mentorship. Undergraduates reported improved self efficacy (p =.001), campus connection (p <.001), professional development (p ≤.002), and self advocacy (p <.001) after two academic years. Graduate student mentors increased their understanding about learning disabilities and used their understanding to support both their mentees and other students they worked with. Council members identified and created opportunities for delivering learning disability-related trainings to faculty, mentors and advisors on campus, and for enhancing coordination of student services related to learning and related disorders. Disability-focused activities became integrated in broader campus activities regarding diversity. This research explicates a role that college campuses can play in fostering the wellbeing and the academic and career development of its students with developmental learning and related disorders. It offers an empirically tested campus-based model that is multilevel, holistic, and strengths-based for supporting positive outcomes of young people with learning disabilities in STEM. Moreover, findings advance the knowledge of supports and skills that are important for self-regulating and navigating complex and multi-faceted disability-related challenges within both the post-secondary educational environment and the young adults’ sociocultural context. (shrink)

Academic dishonesty is an insidious problem that besets most tertiary institutions, where considerable resources are expended to prevent and manage students' dishonest actions within academia. Using a mixed retrospective and prospective design this research investigated Gottfredson and Hirschi's self-control theory as a possible explanation for academic dishonesty in 264 university students. The relationship between academic dishonesty and general criminality was also examined. A significant but small to moderate relationship between academic dishonesty and general criminality was present, including correlations with general (...) dishonesty, violent crime and drug offending subcategories. These findings suggested that a general criminological theory may be of use in explaining academic dishonesty, but the overall ability of self-control variables to explain academic dishonesty was not strong. Controlled logistic regressions indicated that a significant positive association with academic dishonesty was only present for one of 6 self-control subscales (self-centeredness), and even this association was only present in the prospective study component. A strong relationship between past and future academic dishonesty was present. Implications of the study for institutions are discussed. (shrink)

A hallmark of skilled motor performance is behavioral flexibility – i.e., experts can not only produce a movement pattern to reliably achieve a given task goal, but also possess the ability to change that movement pattern to fit a new context. In this perspective article, we briefly highlight the factors that are critical to understanding behavioral flexibility, and its connection to movement variability, stability, and learning. We then address how practice strategies should be developed from a motor learning standpoint to (...) enhance behavioral flexibility. Finally, we highlight some important future avenues of work that are needed to advance our understanding of behavioral flexibility. We use examples from sport as a context to highlight these issues, especially in regard to elite performance and development. (shrink)

Children with autism spectrum disorder show marked difficulties in reading comprehension, a complex cognitive skill fundamental to successful daily functioning that is associated with core executive functions. However, the neurophysiological mechanisms underlying reading comprehension deficits in these children remain elusive. Twenty-one right-handed males with high-functioning ASD and 23 age-, IQ-, educational level-, sex- and handedness-matched typically developing individuals underwent a reading comprehension test and the semantic verbal fluency test that tapped core executive functions underlying reading comprehension during concurrent prefrontal functional (...) near-infrared spectroscopy measurement. Participants’ information processing efficiency was also assessed. High-functioning ASD children exhibited general reading comprehension [main effect of group: F = 7.58, p = 0.009], selective verbal fluency deficits [Group × category interaction: F = 4.90, p = 0.032] and slower processing speed. Regarding the hemodynamics of the prefrontal cortex, although ASD individuals showed comparable patterns of PFC brain activation to their healthy counterparts, lower PFC intrahemispheric [main effect of group: F = 11.36, p = 0.002] and interhemispheric [main effect of group: F = 7.79, p = 0.008] functional connectivity were evident during the semantic verbal fluency test. At the whole-group level, poorer reading comprehension performance was associated with poorer performance in the semantic verbal fluency test. Moreover, poorer semantic verbal fluency test performance was associated with slower information processing speed, which is associated with reduced left medial PFC functional connectivity. Abnormal intrahemispheric and interhemispheric prefrontal hypoconnectivity is associated with deficits in executive processes essential for reading comprehension in ASD. Our study has provided important implications for the neuropsychological and neurophysiological mechanisms underlying reading comprehension deficits in ASD. (shrink)

Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Prolegomenon to the Homeric CentosM. D. UsherHomeric centos are poems made up entirely of verses lifted verbatim, or with only slight modification, from the Iliad and Odyssey. Only a few have survived antiquity. There exist three short Homeric centos in the Palatine Anthology (9.361, 381, 382; cf. Hunger 1978, 98–101), a ten–line cento about Herakles quoted by Irenaeus (Wilken 1967), and a seven– line cento grafitto inscribed on the (...) leg of a statue of Memnon in Egypt, which dates from the reign of Hadrian (Bernand 1960, 111–13; Bowie 1990, 65). There are also several cento–like incantations from the Greek Magical Papyri that use lines from Homer (Maltomini 1995). The only Homeric centos we possess in any quantity are the topic of this study. These originated with a Christian bishop named Patricius in the fourth century C.E., and were later expanded by Eudocia Athenaïs, wife of the emperor Theodosius II, in the early fifth.Eudocia's Homeric centos have long been neglected for lack of a complete and authoritative text. The responsibility for this situation rests with the otherwise eminent Homerist, Arthur Ludwich, whose Teubner edition of 1897, the only edition of the centos currently available, is based on a single, partially edited manuscript (Par. graec. suppl. 388: "Codex Mutinensis").1 Pessimism about establishing a reliable text and aesthetic disenchantment with the poem itself have hampered further study: according to Joseph Golega, for example, the Homeric centos are "weder des Druckes noch des Lesens wert" (Golega 1960, 1).Such an assessment lacks understanding and imagination. In his short study of 1979, Kurt Smolak called for a new edition of the centos in no uncertain terms, emphasizing the poem's great heuristic potential (49):Die Zentonen als spezielle Form der spätantiken Homerrezeption erwiesen sich als der Interpretation ihrer oft nicht anerkannten dichterischen Möglichkeiten durchaus zugänglich—dann sind sie doch wohl auch eine [End Page 305] Edition wert! Denn die frühbyzantinische Bibeldichtung kann dem Theologen, Komparatisten und sich auch dem Philologen ein wenig bebautes Arbeitsfeld eröffnen—sofern dieser sich nicht als Zensor im Namen einer klassizistischen Ästhetik versteht.The present study is offered as a prolegomenon to a new, complete edition of Eudocia's poem—a first installment on the larger interpretive program suggested by Smolak.2 It concerns my collation and transcription of a manuscript of the Homeric centos in the collection of the Iviron monastery on Mount Athos, Greece, which I inspected meis oculis in the summer of 1995.3 This hitherto unaccounted–for cento manuscript, datable on palaeographical grounds to the mid–fourteenth century, is one of a type used by Aldus Manutius for the editio princeps of the centos, published in Venice in 1502 (Renouard 1825, 57–62). Ludwich all but ignored Aldus' edition and the important revision of it published by Henricus Stephanus in 1578. His oversight was unfortunate, for the Iviron–Aldus–Stephanus recension of the centos (hereafter simply "Iviron," or "Iviron recension") is completely different from his, and as we shall see, better than his as well.Our investigation begins with the Aldine edition, the preface to which indicates that the text was transcribed and corrected for Aldus by Petrus Candidus, the son or perhaps nephew of Petrus Candidus Decembrius (1399–1477), papal secretary to Nicolas V. This younger Candidus belonged to the Benedictine order of the Camaldunensians, who were housed in the Venetian monastery of St. Michael Murianus. Following the preface of Candidus is a six–line elegiac poem on the centos composed by Scipio Fortiguerra, a member of the Aldine Academy who frequently collaborated with Aldus in preparing printed editions. We can safely infer, therefore, that both Candidus and Fortiguerra had a hand in the production of the editio princeps, and it is likely that the ms or mss they used were Venetian, or at least Italian (cf. Harris 1898, 25–26). That manuscript has yet to resurface, and may no longer exist, though it is possible that Iviron 4464 was once in Venice. The monastery obtained it, according to its librarian Father Theologos, from the personal library of [End Page 306] Maximos Margounios (1549–1602), bishop of Kythera, who... (shrink)

Categorical loudness scaling (CLS) measures provide useful information about an individual’s loudness perception across the dynamic range of hearing. A probability model of CLS categories has previously been described as a multi-category psychometric function (MCPF). In the study, a representative “catalog” of potential listener MCPFs was used in conjunction with maximum-likelihood estimation to derive CLS functions for participants with normal hearing and with hearing loss. The approach of estimating MCPFs for each listener has the potential to improve the accuracy of (...) the CLS measurements, particularly when a relatively low number of data points are available. The present study extends the MCPF approach by using Bayesian inference to select stimulus parameters that are predicted to yield maximum expected information (MEI) during data collection. The accuracy and reliability of the MCPF-MEI approach were compared to the standardized CLS measurement procedure (ISO16832:2006). A non-adaptive, fixed-level, paradigm served as a “gold-standard” for this comparison. The test time required to obtain measurements in the standard procedure is a major barrier to its clinical uptake. Test time was reduced from approximately 15 minutes to approximately 3 minutes with the MEI-adaptive procedure. Results indicated that the test-retest reliability and accuracy of the MCPF-MEI adaptive procedures were similar to the standardized CLS procedure. Computer simulations suggest that the reliability and accuracy of the MEI procedure were limited by intrinsic uncertainty of the listeners represented in the MCPF catalog. In other words, the MCPF provided insufficient predictive power to significantly improve adaptive-tracking efficiency under practical conditions. Concurrent optimization of both the MCPF catalog and the MEI-adaptive procedure have the potential to produce better results. Regardless of the adaptive-tracking method used in the CLS procedure, the MCPF catalog remains clinically useful for enabling maximum-likelihood determination of loudness categories. (shrink)

Recent advances in wireless technologies have led to the development of intelligent, in-vehicle safety applications designed to share information about the actions of nearby vehicles, potential road hazards, and ultimately predict dangerous scenarios or imminent collisions. These vehicle safety communication (VSC) technologies rely on the creation of autonomous, self-organizing, wireless communication networks connecting vehicles with roadside infrastructure and with each other. As the technical standards and communication protocols for VSC technologies are still being developed, certain ethical implications of these new (...) information technologies emerge: Coupled with the predicted safety benefits of VSC applications is a potential rise in the ability to surveil a driver engaging in her everyday activities on the public roads. This paper will explore how the introduction of VSC technologies might disrupt the “contextual integrity” of personal information flows in the context of highway travel and threaten one’s “privacy in public.” Since VSC technologies and their related protocols and standards are still in the developmental stage, the paper will conclude by revealing how close attention to the ethical implications of the remaining design decisions can inform and guide designers of VSC technologies to create innovate safety applications that increase public safety, but without compromising the value of one’s privacy in public. (shrink)

Vedic Voices: Intimate Narratives of a Living Andhra Tradition. By David M. Knipe. New York: Oxford University Press, 2015. Pp. xxii + 340, illus. $35.

In lieu of an abstract, here is a brief excerpt of the content:Form and Discontent*Rosmarie Waldrop (bio)1. Composition as ExplanationIn the beginning there is Gertrude Stein, who says in “Composition as Explanation”: “Everything is the same except composition and as the composition is different and always going to be different everything is not the same” [520].I could also say, in the beginning is Aristotle: “the fable is simply this, the combination of the incidents” [1460].2. A Look AroundThe forms that have (...) been striking me as “wild” have tended to be Steinian in this sense of stressing the horizontal, the axis of composition. I’m most struck by 3 tendencies: one is literally spatial composition, e.g. Susan Howe’s work; another, an emphasis on discontinuity, leaps on the level of syntax, of logic, of grammar. Breaks that do not immediately fold back into a smooth unity and may occur in mid-sentence:I was on my way from Carthage, it was night. It is not wax I am scorching was dead about her with knots.—Norma Cole, MarsI hide behind a category by misbehaving.—Carla Harryman, Under the BridgeLoop conceived in a line, the spine with its regions, reasons. On another, sweaters hang by the wrist to dry. The list is sweet. You lie. The eye is met by the season.—Ron Silliman, ParadiseYou took my temperature which I had meant to save for a more difficult day.—Rosmarie Waldrop, The Reproduction of ProfilesWent out so I’d take the car and a whole system of banking and money is based on a hierarchy.—Leslie Scalapino, Considering How Exaggerated the Music IsROAST POTATOESRoast Potatoes for.—Gertrude Stein, “Tender Buttons”Or, a subtler example, Mei-mei Berssenbrugge’s almost unnoticeable shifts from one grammatical structure into another: [End Page 54]Never mind if he calls, the places you get through inwardness take time, and to drift down to the shore of the island, you know by the sand moving, even the coarse sand here It’s hard to say if you can even stand up, there....[13]The third tendency is mathematical. There is a lot of counting. Not stresses, not even syllables—I’m not considering that most unimaginative bunch, the new formalists—but words per line, sentences per paragraph. You all know about Ron Silliman’s love for the Fibonacci number series, or Lyn Hejinian’s My Life, which began with 37 sections of 37 sentences each. When she published a second edition at age 45, she added 8 sentences to each section plus 8 new sections.Jacques Roubaud: “No ideas but in numbers” [291].Then, in a somewhat more remote way, a number of people use ideas of permutation. For example, Jackson Mac Low’s 4 Trains, of which I will quote the first two stanzas:Train rule atom intricate nitrogen. Rule unusual leotard entropy. Atom train ostrich might. Intricate nitrogen train rule intricate casual atom train entropy. Nitrogen intricate train rule ostrich genealogy entropy nitrogen.Rule unusual leotard entropy. Unusual nitrogen unusual social unusual atom leotard. Leotard entropy ostrich train atom rule dies. Entropy nitrogen train rule ostrich pope yearly.[7]As Zukofsky puts it: “[Thus] poetry may be defined as an order of words that as movement and tone (rhythm and pitch) approaches in varying degrees the wordless art of music as a kind of mathematical limit” [27].All these examples draw attention to arrangement, composition. They all listen to language. I once wrote:I don’t even have thoughts, I say, I have methods that make language think, take over and me by the hand. Into sense or offense, syntax stretched across rules, relations of force, fluid the dip of the plumb line, the pull of eyes.... No beginnings. All unrepentant middle.[A Form / of Taking / It All 74]And none of these forms are “organic form.” None relies primarily on metaphor, though from the Romantics on poetry has been more or less identified with it.3. Frameworka. HistoricalLet me step back for a moment to the beginnings of the concept of organic form, what it reacted against.When Goethe started to make a splash writing free verse, around 1770, the dominant aesthetic... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Opining the articuli fidei:Thomas Aquinas on the Heretic’s Assent to the Articles of FaithM. V. DoughertyTHOMAS AQUINAS’S ACCOUNT of the infused virtue (habitus) of faith presupposes that some intrinsically intelligible truths are beyond the range of the natural cognitive abilities of human beings. The possession of the virtue of faith allows the believer to transcend certain natural epistemic limitations so that he can assent to truths that are necessary (...) for salvation. Consonant with the Catholic theological tradition, Aquinas refers to such truths as the articles of faith (articuli fidei), and stock examples include propositions concerning the Trinity and the Incarnation.1In light of the many and well-known texts from the Corpus Thomisticum that highlight the disproportion or incommensurability between the articles of faith and the natural cognitive abilities of human beings, it would not be unreasonable for one to assume that faith is required to assent to such articles of faith [End Page 1] in this life. Such an interpretive assumption could be expressed as:A1: A human being can assent to the articles of faith in this life if and only if the human being is fortified with the infused virtue of faith.One might be led to ascribe A1 to Aquinas when one considers that he criticizes the Pelagians precisely for maintaining that the assent to matters of faith is caused by nothing other than free will.2 Still further, one might think that strong evidence for A1 is Aquinas’s claim that “free will does not suffice for believing, since those things that are of faith are above reason.”3I argue, however, that A1’s identification of the virtue of faith as a necessary condition for the assent to the articles of faith does not adequately reflect Aquinas’s position, despite the many texts that may suggest such a view.4 That Aquinas does not endorse A1 can be made evident by examining his largely overlooked account of the epistemic state of the heretic (haereticus). To be sure, most commentators who explore the Thomistic treatment of heresy focus on the psychology of error underlying the heretic’s denial of one or more of the articles of faith.5 In the present paper I take an alternate path, however, focusing on those epistemic acts whereby the heretic gets its [End Page 2] right, so to speak, by correctly assenting to some of the articles of faith. Aquinas maintains that the heretic does not possess the infused virtue of faith yet still assents to all the articles of faith except for the one or more articles that he denies. Bereft of faith, the heretic “holds those things that are of faith by another mode than through faith.”6 This seemingly anomalous epistemic condition deserves consideration.7I. Intellects without FaithThe heretic appears to be cognitively privileged, since without faith he assents to the things that are of faith, seemingly overcoming without divine assistance the aforementioned disproportion between the limited range of reason and the articles of faith. Aquinas is aware of the apparent difficulty; in the Summa theologiae he defuses the rather unusual objection that heretics appear to have greater cognitive capacities than the faithful, since heretics routinely and unassistedly assent to those higher truths without possessing the virtue of faith.8 Aquinas concludes that the heretic holds the articles of faith by opinion (opinio), not faith.What makes one a heretic? Frequently Aquinas identifies obstinacy (pertinacia, instantia) as a necessary condition for heresy.9 The cause of heresy is at times identified with pride [End Page 3] (superbia).10 On Aquinas’s account, heresy is a species of unbelief (infidelitas) and every heretic is a schismatic.11 But the heretic does get many things right. If one were to deny all of the articles of faith, one would not qualify as a heretic, but would simply be a nonbeliever or an apostate. So, apart from the denial of an article (or a few articles) that specifies heretics as the distinct kind of heretic they happen to be, heretics for the most part succeed in assenting to most—but not all—of the articles of faith.Although the... (shrink)

Книга представляет собой систематический научный труд. Это принципиально новая наука! Здесь нет механики! Исследование мироздания - "качественное", и законы, есть законы.

Selected articles on Marxism, nationalism, and humanism by a radical humanist leader and Communist international; includes study on his life and work.

Learning a mapping involves finding regularities in a training set and generalization to novel patterns. Clark & Thornton's type distinction has been discussed in terms of generalization, but has limited value in this respect. However, in terms of detection of regularities in the training set, the distinction is more valid, as it provides a measure of complexity and correlates with the size of search space.

System of References To keep footnotes to a minimum, references to classical sources are incorporated into the body of the narrative, normally in the ...

In this issue we are publishing articles criticizing the " gang of four" selected from recent sources in the People's Republic of China. The major recent sources in the People's Republic of China. The major theoretical criticism centers around the idea and theory of "bourgeois rights" attributed to the "gang of four.".

Quantum electrodynamics is the theory of electrons and other elementary charged particles, interacting through the exchange of light quanta. Albert Einstein introduced the light quantum in 1905, but for about three decades physicists applied quantum ideas mainly in theories of the structure and behavior of matter, not to electromagnetic radiation itself, which was always treated semi-classically. This began to change after 1923 with the discovery of the Compton effect and its kinematic description by Arthur Compton and Peter Debye, based on (...) the light quantum. In this paper we review the study of high-energy radiation that led to Compton's discovery. We discuss the analysis of the intensity distribution of Compton-scattered radiation that together with the ''new'' quantum theory beginning in 1925, resulted in the development, especially by Pascual Jordan and Paul Dirac, of a quantum theory of electromagnetic radiation in interaction with matter. (shrink)

We exhibit a 10-element semigroup Q such that the question Does a given quasi-identity hold in Q? is co-NP-complete while the question Does a given identity hold in Q? can be answered in linear time.